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Hope you are well! Below is our newsletter for November, 2023. I wanted to make sure you got it. Warm regards,
Newsletter | November 2023
Research Spotlight Liver and muscle health are intimately connected. Nutritional strategies that support liver detoxification are beneficial to muscle recovery. Computational–in silico–molecular systems’ biology analysis of supplementation of calcium and potassium glucarate salts and their metabolite D-glucaric acid (GA) reveals their positive effect on mitigation of liver detoxification via four specific molecular pathways: (1) ROS production, (2) deconjugation, (3) apoptosis of hepatocytes, and (4) β-glucuronidase synthesis. GA improves liver detoxification by downregulating hepatocyte apoptosis, reducing glucuronide deconjugates levels, reducing ROS production, and inhibiting β-Glucuronidase enzyme that reduces re-absorption of toxins in hepatocytes. Results from this in silico study provide an integrative molecular mechanistic systems explanation for the mitigation of liver toxicity by GA.. Download this pioneering and well-received journal article published in “NUTRIENTS”. Statement From Our Chairman & CEOIn 2003, when I went back to M.I.T. to pursue my PhD in Systems Biology to create the first computational platform that could mechanistically model complex biological processes and diseases, that was thought impossible. Four years later, in 2007, I invented CytoSolve and demonstrated its viability to scalably build and compute large-scale models. Following that, our team published major papers in peer-reviewed journals to validate the CytoSolve platform. One of the important milestones was when CytoSolve received an FDA allowance for a multi-combination therapeutics for Pancreatic Cancer discovered completely in CytoSolve. Today, CytoSolve has pioneered an entire industry. Our Research Division has partnerships with over 40 major scientific institutions. Our Testing Division is helping companies globally formulate products that really work long before wasting time on expensive in vitro and in vivo testing. More recently, our growing Discovery Division is making breakthroughs in identifying synergistic combinations of molecules with high efficacy and low toxicity – discoveries that could not be possible with conventional methods. We have begun this newsletter to keep you up-to-date of the industry CytoSolve is defining. I look forward to exploring how CytoSolve can help you. Please feel free to set up time with me directly: Book an appointment with Dr. Shiva Ayyadurai. Warmest regards,
Industry NewsAmerican Society for Clinical Pharmacology & Therapeutics (ASCPT) is one of the most respected scientific associations in the world. CytoSolve was honored to deliver the State of the Art Lecture to over 1,500 scientists and industy leaders. This video will provide you a wonderful insight into the development of CytoSolve and its power to revolutionize health and medicine.
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