CYTOSOLVE CASE STUDY: The Natural Vet – REDOXX®
The Natural Vet’s REDOXX® formulation has been shown to help horses, dogs, and cats improve immune system, lower anxiety, and increase energy. In this study, a systematic literature review is conducted to identify the molecular pathways affecting immune health, anxiety and energy metabolism. These molecular pathways are converted to individual mathematical models, each model is validated, and the plurality of models are integrated with the CytoSolve® computational systems biology platform to produce an integrative model of immune health, anxiety, and energy metabolism.
The results from the systematic review revealed three major biological systems that govern anxiety: 1) Endocannabinoid Synthesis; 2) NMDAR Signaling; and, 3) Oxidative Stress. The results from the CytoSolve in silico modeling demonstrate that REDOXX ingredients synergistically alleviate anxiety by increasing endocannabinoids, downregulating NMDAR singaning, and dowregulating oxidative stress.
CytoSolve’s systematic review revealed two major biological systems involved in immune function: 1) TLR-4 signaling pathway; and, 2) IL-6 signaling pathway. REDOXX ingredients synergistically improved immune function by downregulating TLR-4 signaling pathway and downregulating IL-6 signaling pathway.
The results from the systematic review revealed three major biological systems that govern energy metabolism: 1) Glycolysis pathway; and, 2) TCA Cycle. The results from the CytoSolve in silico modeling demonstrate that REDOXX ingredients synergistically improve energy metabolism by upregulating both glycolysis and TCA cycle.
CYTOSOLVE CASE STUDY: The Natural Vet – Bug Check®
The Natural Vet®’s Bug Check® has been shown to help improve pest repellent action in mammals including equine, canine, feline, sheep and bovine. However, the molecular mechanistic understanding of the effect of bioactive compounds in Bug Check, individually and in combination, on pest repellent action needs further elucidation. In this study, a systematic literature review is conducted to identify the molecular pathways affecting pet repellent action. These molecular pathways are converted to individual mathematical models, each model is validated, and the plurality of models are integrated with the CytoSolve® computational systems biology platform to produce an integrative model of pet repellent action. The results from the systematic review reveal three major biological systems that govern pest repellent action: 1) Oxidative Stress; 2) Transglutaminase Synthesis Pathway; and, 3) Lactic Acid Synthesis pathway. The results from the CytoSolve in silico modeling demonstrate that Bug Check ingredients synergistically alleviate pest repellent action by increasing transglutaminase, downregulating lactic acid production, and downregulating oxidative stress.