Vata-PittaT™ combination screening uses CytoSolve to quantify eight-herb synergy across detox, sleep-support, neuro-relaxation, and migraine-associated pathway modules
Vata-PittaT™ Vata-PittaT™ is a herbal tea formulated as a proprietary blend of eight Indigenous Indian herbs—jatamansi, sankan phusphi, ajwain, nutmeg, amla, poppy seeds, licorice, and brahmi—positioned to support the body’s natural detox process and help balance Vata-Pitta. The product narrative highlights potential functional support for sleep, relaxation, and migraine-related discomfort, with a free “Your Body Your System” analysis offered to help individuals select the best tea for their needs.
Challenge
Vata-PittaT™ is a multi-herb formulation intended to support several functional outcomes simultaneously (detox support, relaxation state, sleep quality, and migraine-related support). The scientific challenge for such blends is that:
- Each herb can influence multiple molecular targets and biological systems simultaneously
- Desired outcomes may depend on synergy—coordinated effects across neuroendocrine, inflammatory, and oxidative pathways—rather than any single ingredient
- Traditional testing struggles to efficiently isolate individual contributions and emergent blend behavior across multiple domains in parallel
A systems-level method was required to evaluate the blend as it is used in practice—as a combination—while still quantifying individual ingredient effects.
How CytoSolve Helped
CytoSolve applied its in silico combination screening workflow to characterize Vata-PittaT™ as an integrated biological intervention.
Systems architecture for Vata-PittaT™
CytoSolve translated the product’s intended benefits into a pathway blueprint organized into four interacting subsystem modules:
- Detox and clearance biology (inflammatory tone, oxidative balance, endogenous clearance signaling)
- Sleep regulation module (neuroendocrine-adjacent signaling proxies and sleep–stress coupling)
- Relaxation / stress-response module (stress adaptation signaling and autonomic balance proxies)
- Migraine-associated pathway module (neuroinflammatory and vascular-tone–adjacent signaling proxies)
These modules were integrated to preserve cross-talk—for example, how inflammatory tone and oxidative balance can influence sleep quality and neuro-sensitization, and how stress-response signaling can interact with relaxation state.
Ingredient encoding and model inputs
- Encoded the eight ingredients—jatamansi, sankan phusphi, ajwain, nutmeg, amla, poppy seeds, licorice, and brahmi—as mechanistic perturbations mapped across the relevant subsystem modules
- Used a use-relevant dosing framework consistent with preparation instructions (boiling water, steeping, serving size)
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Single-ingredient baselining
- Simulated each herb independently to generate pathway “fingerprints,” identifying which subsystems each ingredient most strongly influences (e.g., detox/oxidative balance vs. relaxation vs. sleep-related signaling).
Combination screening and synergy analysis
- Simulated the full eight-herb blend and compared it to the expected additive envelope derived from single-ingredient runs
- Quantified synergy where the blend showed:
- Broader coverage (simultaneous modulation across detox, sleep, and relaxation modules)
- Deeper effects (non-additive reductions in stress/inflammation proxies or stronger relaxation-associated signaling shifts than any single herb)
- Evaluated coordinated behavior consistent with the intended “Vata-Pitta balancing” profile: calming/relaxation-supportive signaling coupled with detox and neuroinflammatory moderation
Personalization enablement (Your Body Your System)
- Structured outputs to support education-led personalization: mapping the blend’s subsystem signature to an individual’s “Your Body Your System” profile to guide tea selection and use recommendations.
- Broader coverage (simultaneous modulation across detox, sleep, and relaxation modules)
- Deeper effects (non-additive reductions in stress/inflammation proxies or stronger relaxation-associated signaling shifts than any single herb)