Our Partners and Collaborations Validating Our Platform

Peer- Reviewed Validation

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USC Keck School of Medicine completed peer-reviewed validation of CytoSolve’s pericytes systems architecture, resulting in major Nature Neuroscience publication.

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University of Toronto’s Keating Lab completed peer-reviewed validation of CytoSolve’s MSC microenvironment architecture, published in Oxford University Press journal.

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MIT’s Dewey Lab completed peer-reviewed validation of CytoSolve’s nitric oxide model, published in Cell’s Biophysical Journal.


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Tufts School of Medicine completed peer-reviewed validation of CytoSolve’s low-grade chronic inflammation models, published in Clinical Nutrition ESPEN.

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A peer-reviewed study validated CytoSolve®’s modular systems architecture for scalable, accurate modeling of shear-stress–induced nitric oxide production in vascular endothelium.

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A peer-reviewed study validated CytoSolve®’s modular systems architecture for scalable, accurate modeling of shear-stress–induced nitric oxide production in endothelial cells.

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A modular systems architecture using CytoSolve® enabled scalable integration of endothelial signaling pathways to accurately model shear-stress-induced nitric oxide production.

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A peer-reviewed study validated CytoSolve®’s systems architecture to organize and model the complex molecular interactome of acute myeloid leukemia.

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A peer-reviewed study validated CytoSolve®’s molecular systems architecture for organizing and modeling the complex interactome of the acute myeloid leukemia microenvironment.

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CytoSolve® enabled a peer-reviewed, systems-level molecular architecture of periodontitis, validated through comprehensive literature synthesis and experimental alignment.

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CytoSolve® independently validated synergistic efficacy of a multi-ingredient equine joint formula through mechanistic, systems-level in silico combination screening.

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CytoSolve® enabled peer-reviewed systems-level molecular architecture of periodontitis, integrating host–microbiome interactions through rigorous literature synthesis and experimental alignment validation publication.

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CytoSolve® provided peer-reviewed, literature-grounded mechanistic validation to support Walter Reed Army Research Institute–relevant evaluation of multi-ingredient supplement interactions.

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CytoSolve® provided a validated, peer-reviewed computational framework revealing mechanistic, reproducible pathways by which D-glucaric acid enhances liver detoxificatio

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CytoSolve® enabled peer-reviewed, reproducible systems biology modeling revealing how green tea bioactives mechanistically promote immune tolerance following organ transplantation.

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CytoSolve® provided a peer-review–ready systems biology architecture enabling mechanistic, scalable modeling of interferon-driven autoimmune biology across multiple cell types

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CytoSolve® and UHN validated a multi-scale, peer-review-ready systems architecture mapping human knee osteoarthritis from anatomy to evidence-linked molecular reactions.

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CytoSolve® enabled UCLA investigators to validate integrated, multi-cell immune signaling models of neuromyelitis optica for therapeutic hypothesis generation.

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CytoSolve® provided a peer-review-ready systems biology platform enabling mechanistic validation of neuromyelitis optica immune signaling for therapeutic discovery initiatives.

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CytoSolve® integrated validated pain-pathway models to quantify the synergistic effects of apigenin and hesperidin, providing peer-reviewed mechanistic evidence across inflammation, nociception, and oxidative stress, strengthening the scientific foundation for Ramard's Joint Pain Formula.

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CytoSolve® integrated validated pain-pathway models to quantify the synergistic effects of apigenin and hesperidin, providing peer-reviewed mechanistic evidence across inflammation, nociception, and oxidative stress, strengthening the scientific foundation for Ramard's Joint Pain Formula.

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CytoSolve® facilitated the discovery of a novel FDA-approved drug combination for pancreatic cancer treatment by employing a peer-reviewed, mechanistically driven approach. This case study emphasizes the use of peer-reviewed scientific literature and validated mechanistic models to identify an optimized drug combination, accelerating the regulatory process.

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CytoSolve® partnered with the Harvard Stem Cell Institute (HSCI) to model the mechanisms of spinal muscular atrophy (SMA) in silico. This collaboration provided systems-level insights into motor neuron degeneration, enabling a deeper understanding of disease mechanisms and potential therapeutic intervention strategies based on peer-reviewed scientific validation.

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CytoSolve® validated Juice Plus+ antioxidant formulation’s effectiveness in combating aging-related oxidative stress through peer-reviewed computational analysis.

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CytoSolve® and Wapiti Labs developed a systems architecture linking Elk Velvet Antler bioactives to seventeen biological functions and health mechanisms, grounded in peer-reviewed literature.

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CytoSolve® provided peer-reviewed, reproducible systems biology validation of green tea bioactives, revealing their mechanistic role in promoting immune tolerance following organ transplantation in collaboration with City of Hope Foundation.

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CytoSolve® provided peer-reviewed mechanistic validation to support the USP’s evaluation of multi-ingredient supplement interactions and safety for military personnel.

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CytoSolve® integrated six molecular relaxation pathways to quantify individual and combined ingredient effects, accelerating mechanistic insights and formulation optimization strategies for British American Tobacco (BAT). This peer-reviewed case study demonstrates how computational modeling can enhance the understanding of complex biological systems and inform innovation in consumer products related to harm reduction.