Esketamine nasal spray appears both effective and fast acting for treatment-resistant depression, but questions still remain about the drug’s safety.
Researchers published the results of a phase III clinical trial of the drug this week in the American Journal of Psychiatry. The trial was designed to test the efficacy and safety of Spravato, the FDA-approved esketamine nasal spray developed by Janssen Pharmaceuticals.
The double-blind, active-controlled study included nearly 200 patients across 39 outpatient centers from 2015 to 2017.
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