CytoSolve Collaborates With World-Renowned Scientists at Leading Universities, Research Institutions and Foundations to Develop and Validate Large-Scale Systems Architecture and Models of Disease and Complex Biological Phenomena.
Pioneering a 23rd Century Research Paradigm
From the systems biology perspective, living organisms can be viewed as being comprised of dynamic networks of biochemical reactions. The origin of disease is characterized by the disruption of one or more signaling cascades, which may arise due to defects at the molecular level. These events ultimately result in the symptomatic manifestation of disease, due to disturbances in usual functions of the cascades involved. Computational modeling of molecular pathways acts as a backbone for the development of disease models. To functionalize computational models as a disease model, one or more signaling molecules function are altered. In complex diseases, there are numerous cells involving different cascades. In such case, an integrative modeling approach assisted by the CytoSolve platform, sheds more light on the effects of the dysfunction mediated by molecular pathways. This could potentially lead to the identification of new biomarkers, targets, and ultimately, therapeutics with beneficial effects in an overall sense rather than those arising from targeting a single molecule. CytoSolve collaborates with leading research institutions in the development of complex and large-scale molecular systems architectures. These architectures are used as a framework in the development of predictive and quantitative models of disease and complex biological phenomena.
Enabling Our Partners to Innovate 21st Century Solutions, Now!
Traditional methods of target discovery have relied on in vitro/ in vivo studies and sometimes molecular dynamics analysis. However, these methods are ad hoc and do...Read more
Recent research has focused on identifying combination of drugs or dietary supplements with maximum effect at minimal dosage levels. However, the in vitro and in vivo...Read more
Discoveries about the molecular basis of disease provide unprecedented opportunities to find new medicines. Discovery and formulation of new drug takes more than 14...Read more
Mechanistic understanding of complex biological phenomena is needed at a system level to identify novel biomarkers that can be used for better diagnostics of a...Read more
Safety and Toxicity
Diverse responses of target or biomarker induced toxicity through different signaling pathways are identified through systematic literature review. Computational...Read more