Partnering with CytoSolve
Nutritional Supplement, Ingredients and Functional Food Manufacturers
The CytoSolve platform enables product manufacturers such as nutritional supplement companies, cosmeceutical companies, ingredient suppliers, functional food companies etc. to gain insights to understand how particular ingredients and/or single molecules act upon a particular indication or molecular mechanism of action. The detailed insights provide manufacturers and ingredient suppliers a powerful capability to determine how to formulate truly efficacious products and articulate the value of those ingredients and formulations to their customers and consumers.
CYTOSOLVE CASE STUDY: One Of The Largest Aromatherapy Companies
Several clinical and animal studies have shown that bioactive compounds in cinnamon either as whole cinnamon or cinnamon extract affect blood glucose and insulin signaling. However, the molecular mechanistic understanding of the effect of bioactive compounds in cinnamon extracts such as cinnamon bark oil, individually and in combination are not fully elucidated. In this study, a systematic literature review is conducted to identify the molecular pathways affecting glucose metabolism. The molecular pathways of glucose metabolism are converted to individual mathematical models, each model is validated, and the plurality of models are integrated with the CytoSolve® computational systems biology platform to produce an integrative model of glucose metabolism. CytoSolve provides for the dynamic integration of molecular pathway models in silico (through mathematical modeling on a computer), to understand synergistic effects of multi-ingredient natural products on molecular pathways of biological processes. Combination of all the bioactive molecules at the recommended dose levels in cinnamon bark oil is tested in silico. The results from the systematic review reveal three major biological systems that govern glucose metabolism: 1) Glut-4 translocation; 2) Inflammation; and, 3) Glucose conversion by α-Glucosidase. The results from the CytoSolve in silico modeling demonstrate that cinnamon bark oil bioactive compounds synergistically enhance glucose metabolism by increasing Glut-4 translocation, reducing inflammation, and inhibiting glucose conversion by α-Glucosidase.